Insights into the Mechanism of Bovine CD38/NAD+Glycohydrolase from the X-Ray Structures of Its Michaelis Complex and Covalently-Trapped Intermediates

Bovine CD38/NAD(+)glycohydrolase (bCD38) catalyses the hydrolysis of NAD(+) into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR). We solved the crystal structures of the mono N-glycosylated forms of the ecto-domain of bCD38 or the catalytic residue mutant Glu218Gln in thei...

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Detalles Bibliográficos
Autores principales: Egea, Pascal F., Muller-Steffner, Hélène, Kuhn, Isabelle, Cakir-Kiefer, Céline, Oppenheimer, Norman J., Stroud, Robert M., Kellenberger, Esther, Schuber, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329556/
https://www.ncbi.nlm.nih.gov/pubmed/22529956
http://dx.doi.org/10.1371/journal.pone.0034918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329556/
https://www.ncbi.nlm.nih.gov/pubmed/22529956
http://dx.doi.org/10.1371/journal.pone.0034918

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