Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. The reported prevalence of mutations in rhabdomyosarcoma (RMS) varies widely, with recent larger studies suggesting that TP53 mutations in pediatric RMS may be extremely rare. Overexpression of MDM2 also attenuates p53...

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Detalles Bibliográficos
Autores principales: Ognjanovic, Simona, Martel, Ghyslaine, Manivel, Carlos, Olivier, Magali, Langer, Erica, Hainaut, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329663/
https://www.ncbi.nlm.nih.gov/pubmed/22550420
http://dx.doi.org/10.1155/2012/492086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329663/
https://www.ncbi.nlm.nih.gov/pubmed/22550420
http://dx.doi.org/10.1155/2012/492086

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