Mexiletine Differentially Restores the Trafficking Defects Caused by Two Brugada Syndrome Mutations

The human cardiac sodium channel Na(v)1.5 encoded by the SCN5A gene plays a critical role in cardiac excitability and the propagation of action potentials. Na(v)1.5 dysfunctions due to mutations cause cardiac diseases such as the LQT3 form of long QT syndrome, conduction disorders, and Brugada syndr...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreau, Adrien, Keller, Dagmar I., Huang, Hai, Fressart, Véronique, Schmied, Christian, Timour, Quadiri, Chahine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330751/
https://www.ncbi.nlm.nih.gov/pubmed/22529811
http://dx.doi.org/10.3389/fphar.2012.00062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330751/
https://www.ncbi.nlm.nih.gov/pubmed/22529811
http://dx.doi.org/10.3389/fphar.2012.00062

Ejemplares similares