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No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Gene–lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331745/ https://www.ncbi.nlm.nih.gov/pubmed/22415877 http://dx.doi.org/10.2337/db11-0973 |
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author | Scott, Robert A. Chu, Audrey Y. Grarup, Niels Manning, Alisa K. Hivert, Marie-France Shungin, Dmitry Tönjes, Anke Yesupriya, Ajay Barnes, Daniel Bouatia-Naji, Nabila Glazer, Nicole L. Jackson, Anne U. Kutalik, Zoltán Lagou, Vasiliki Marek, Diana Rasmussen-Torvik, Laura J. Stringham, Heather M. Tanaka, Toshiko Aadahl, Mette Arking, Dan E. Bergmann, Sven Boerwinkle, Eric Bonnycastle, Lori L. Bornstein, Stefan R. Brunner, Eric Bumpstead, Suzannah J. Brage, Soren Carlson, Olga D. Chen, Han Chen, Yii-Der Ida Chines, Peter S. Collins, Francis S. Couper, David J. Dennison, Elaine M. Dowling, Nicole F. Egan, Josephine S. Ekelund, Ulf Erdos, Michael R. Forouhi, Nita G. Fox, Caroline S. Goodarzi, Mark O. Grässler, Jürgen Gustafsson, Stefan Hallmans, Göran Hansen, Torben Hingorani, Aroon Holloway, John W. Hu, Frank B. Isomaa, Bo Jameson, Karen A. Johansson, Ingegerd Jonsson, Anna Jørgensen, Torben Kivimaki, Mika Kovacs, Peter Kumari, Meena Kuusisto, Johanna Laakso, Markku Lecoeur, Cécile Lévy-Marchal, Claire Li, Guo Loos, Ruth J.F. Lyssenko, Valeri Marmot, Michael Marques-Vidal, Pedro Morken, Mario A. Müller, Gabriele North, Kari E. Pankow, James S. Payne, Felicity Prokopenko, Inga Psaty, Bruce M. Renström, Frida Rice, Ken Rotter, Jerome I. Rybin, Denis Sandholt, Camilla H. Sayer, Avan A. Shrader, Peter Schwarz, Peter E.H. Siscovick, David S. Stančáková, Alena Stumvoll, Michael Teslovich, Tanya M. Waeber, Gérard Williams, Gordon H. Witte, Daniel R. Wood, Andrew R. Xie, Weijia Boehnke, Michael Cooper, Cyrus Ferrucci, Luigi Froguel, Philippe Groop, Leif Kao, W.H. Linda Vollenweider, Peter Walker, Mark Watanabe, Richard M. Pedersen, Oluf Meigs, James B. Ingelsson, Erik Barroso, Inês Florez, Jose C. Franks, Paul W. Dupuis, Josée Wareham, Nicholas J. Langenberg, Claudia |
author_facet | Scott, Robert A. Chu, Audrey Y. Grarup, Niels Manning, Alisa K. Hivert, Marie-France Shungin, Dmitry Tönjes, Anke Yesupriya, Ajay Barnes, Daniel Bouatia-Naji, Nabila Glazer, Nicole L. Jackson, Anne U. Kutalik, Zoltán Lagou, Vasiliki Marek, Diana Rasmussen-Torvik, Laura J. Stringham, Heather M. Tanaka, Toshiko Aadahl, Mette Arking, Dan E. Bergmann, Sven Boerwinkle, Eric Bonnycastle, Lori L. Bornstein, Stefan R. Brunner, Eric Bumpstead, Suzannah J. Brage, Soren Carlson, Olga D. Chen, Han Chen, Yii-Der Ida Chines, Peter S. Collins, Francis S. Couper, David J. Dennison, Elaine M. Dowling, Nicole F. Egan, Josephine S. Ekelund, Ulf Erdos, Michael R. Forouhi, Nita G. Fox, Caroline S. Goodarzi, Mark O. Grässler, Jürgen Gustafsson, Stefan Hallmans, Göran Hansen, Torben Hingorani, Aroon Holloway, John W. Hu, Frank B. Isomaa, Bo Jameson, Karen A. Johansson, Ingegerd Jonsson, Anna Jørgensen, Torben Kivimaki, Mika Kovacs, Peter Kumari, Meena Kuusisto, Johanna Laakso, Markku Lecoeur, Cécile Lévy-Marchal, Claire Li, Guo Loos, Ruth J.F. Lyssenko, Valeri Marmot, Michael Marques-Vidal, Pedro Morken, Mario A. Müller, Gabriele North, Kari E. Pankow, James S. Payne, Felicity Prokopenko, Inga Psaty, Bruce M. Renström, Frida Rice, Ken Rotter, Jerome I. Rybin, Denis Sandholt, Camilla H. Sayer, Avan A. Shrader, Peter Schwarz, Peter E.H. Siscovick, David S. Stančáková, Alena Stumvoll, Michael Teslovich, Tanya M. Waeber, Gérard Williams, Gordon H. Witte, Daniel R. Wood, Andrew R. Xie, Weijia Boehnke, Michael Cooper, Cyrus Ferrucci, Luigi Froguel, Philippe Groop, Leif Kao, W.H. Linda Vollenweider, Peter Walker, Mark Watanabe, Richard M. Pedersen, Oluf Meigs, James B. Ingelsson, Erik Barroso, Inês Florez, Jose C. Franks, Paul W. Dupuis, Josée Wareham, Nicholas J. Langenberg, Claudia |
author_sort | Scott, Robert A. |
collection | PubMed |
description | Gene–lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13–0.31], P = 1.63 × 10(−6)). All SNPs were associated with 2-h glucose (β = 0.06–0.12 mmol/allele, P ≤ 1.53 × 10(−7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene–lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. |
format | Online Article Text |
id | pubmed-3331745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-33317452013-05-01 No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels Scott, Robert A. Chu, Audrey Y. Grarup, Niels Manning, Alisa K. Hivert, Marie-France Shungin, Dmitry Tönjes, Anke Yesupriya, Ajay Barnes, Daniel Bouatia-Naji, Nabila Glazer, Nicole L. Jackson, Anne U. Kutalik, Zoltán Lagou, Vasiliki Marek, Diana Rasmussen-Torvik, Laura J. Stringham, Heather M. Tanaka, Toshiko Aadahl, Mette Arking, Dan E. Bergmann, Sven Boerwinkle, Eric Bonnycastle, Lori L. Bornstein, Stefan R. Brunner, Eric Bumpstead, Suzannah J. Brage, Soren Carlson, Olga D. Chen, Han Chen, Yii-Der Ida Chines, Peter S. Collins, Francis S. Couper, David J. Dennison, Elaine M. Dowling, Nicole F. Egan, Josephine S. Ekelund, Ulf Erdos, Michael R. Forouhi, Nita G. Fox, Caroline S. Goodarzi, Mark O. Grässler, Jürgen Gustafsson, Stefan Hallmans, Göran Hansen, Torben Hingorani, Aroon Holloway, John W. Hu, Frank B. Isomaa, Bo Jameson, Karen A. Johansson, Ingegerd Jonsson, Anna Jørgensen, Torben Kivimaki, Mika Kovacs, Peter Kumari, Meena Kuusisto, Johanna Laakso, Markku Lecoeur, Cécile Lévy-Marchal, Claire Li, Guo Loos, Ruth J.F. Lyssenko, Valeri Marmot, Michael Marques-Vidal, Pedro Morken, Mario A. Müller, Gabriele North, Kari E. Pankow, James S. Payne, Felicity Prokopenko, Inga Psaty, Bruce M. Renström, Frida Rice, Ken Rotter, Jerome I. Rybin, Denis Sandholt, Camilla H. Sayer, Avan A. Shrader, Peter Schwarz, Peter E.H. Siscovick, David S. Stančáková, Alena Stumvoll, Michael Teslovich, Tanya M. Waeber, Gérard Williams, Gordon H. Witte, Daniel R. Wood, Andrew R. Xie, Weijia Boehnke, Michael Cooper, Cyrus Ferrucci, Luigi Froguel, Philippe Groop, Leif Kao, W.H. Linda Vollenweider, Peter Walker, Mark Watanabe, Richard M. Pedersen, Oluf Meigs, James B. Ingelsson, Erik Barroso, Inês Florez, Jose C. Franks, Paul W. Dupuis, Josée Wareham, Nicholas J. Langenberg, Claudia Diabetes Genetics/Genomes/Proteomics/Metabolomics Gene–lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13–0.31], P = 1.63 × 10(−6)). All SNPs were associated with 2-h glucose (β = 0.06–0.12 mmol/allele, P ≤ 1.53 × 10(−7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene–lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. American Diabetes Association 2012-05 2012-04-13 /pmc/articles/PMC3331745/ /pubmed/22415877 http://dx.doi.org/10.2337/db11-0973 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Genetics/Genomes/Proteomics/Metabolomics Scott, Robert A. Chu, Audrey Y. Grarup, Niels Manning, Alisa K. Hivert, Marie-France Shungin, Dmitry Tönjes, Anke Yesupriya, Ajay Barnes, Daniel Bouatia-Naji, Nabila Glazer, Nicole L. Jackson, Anne U. Kutalik, Zoltán Lagou, Vasiliki Marek, Diana Rasmussen-Torvik, Laura J. Stringham, Heather M. Tanaka, Toshiko Aadahl, Mette Arking, Dan E. Bergmann, Sven Boerwinkle, Eric Bonnycastle, Lori L. Bornstein, Stefan R. Brunner, Eric Bumpstead, Suzannah J. Brage, Soren Carlson, Olga D. Chen, Han Chen, Yii-Der Ida Chines, Peter S. Collins, Francis S. Couper, David J. Dennison, Elaine M. Dowling, Nicole F. Egan, Josephine S. Ekelund, Ulf Erdos, Michael R. Forouhi, Nita G. Fox, Caroline S. Goodarzi, Mark O. Grässler, Jürgen Gustafsson, Stefan Hallmans, Göran Hansen, Torben Hingorani, Aroon Holloway, John W. Hu, Frank B. Isomaa, Bo Jameson, Karen A. Johansson, Ingegerd Jonsson, Anna Jørgensen, Torben Kivimaki, Mika Kovacs, Peter Kumari, Meena Kuusisto, Johanna Laakso, Markku Lecoeur, Cécile Lévy-Marchal, Claire Li, Guo Loos, Ruth J.F. Lyssenko, Valeri Marmot, Michael Marques-Vidal, Pedro Morken, Mario A. Müller, Gabriele North, Kari E. Pankow, James S. Payne, Felicity Prokopenko, Inga Psaty, Bruce M. Renström, Frida Rice, Ken Rotter, Jerome I. Rybin, Denis Sandholt, Camilla H. Sayer, Avan A. Shrader, Peter Schwarz, Peter E.H. Siscovick, David S. Stančáková, Alena Stumvoll, Michael Teslovich, Tanya M. Waeber, Gérard Williams, Gordon H. Witte, Daniel R. Wood, Andrew R. Xie, Weijia Boehnke, Michael Cooper, Cyrus Ferrucci, Luigi Froguel, Philippe Groop, Leif Kao, W.H. Linda Vollenweider, Peter Walker, Mark Watanabe, Richard M. Pedersen, Oluf Meigs, James B. Ingelsson, Erik Barroso, Inês Florez, Jose C. Franks, Paul W. Dupuis, Josée Wareham, Nicholas J. Langenberg, Claudia No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels |
title | No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels |
title_full | No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels |
title_fullStr | No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels |
title_full_unstemmed | No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels |
title_short | No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels |
title_sort | no interactions between previously associated 2-hour glucose gene variants and physical activity or bmi on 2-hour glucose levels |
topic | Genetics/Genomes/Proteomics/Metabolomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331745/ https://www.ncbi.nlm.nih.gov/pubmed/22415877 http://dx.doi.org/10.2337/db11-0973 |
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