The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes

High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)–controlled carbohydrate (CHO) oxidation, which contributes to muscle insulin resistance. We aimed to reveal molecular changes underpinning this process in resting and exercising humans. We also tested whether pharmacological activation o...

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Detalles Bibliográficos
Autores principales: Constantin-Teodosiu, Dumitru, Constantin, Despina, Stephens, Francis, Laithwaite, David, Greenhaff, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331777/
https://www.ncbi.nlm.nih.gov/pubmed/22315317
http://dx.doi.org/10.2337/db11-0799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331777/
https://www.ncbi.nlm.nih.gov/pubmed/22315317
http://dx.doi.org/10.2337/db11-0799

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