A unique regulatory phase of DNA methylation in the early mammalian embryo

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methyl cytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and to...

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Detalles Bibliográficos
Autores principales: Smith, Zachary D., Chan, Michelle M., Mikkelsen, Tarjei S., Gu, Hongcang, Gnirke, Andreas, Regev, Aviv, Meissner, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331945/
https://www.ncbi.nlm.nih.gov/pubmed/22456710
http://dx.doi.org/10.1038/nature10960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331945/
https://www.ncbi.nlm.nih.gov/pubmed/22456710
http://dx.doi.org/10.1038/nature10960

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