Allosteric Analysis of Glucocorticoid Receptor-DNA Interface Induced by Cyclic Py-Im Polyamide: A Molecular Dynamics Simulation Study

BACKGROUND: It has been extensively developed in recent years that cell-permeable small molecules, such as polyamide, can be programmed to disrupt transcription factor-DNA interfaces and can silence aberrant gene expression. For example, cyclic pyrrole-imidazole polyamide that competes with glucocor...

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Detalles Bibliográficos
Autores principales: Wang, Yaru, Ma, Na, Wang, Yan, Chen, Guangju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331974/
https://www.ncbi.nlm.nih.gov/pubmed/22532842
http://dx.doi.org/10.1371/journal.pone.0035159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331974/
https://www.ncbi.nlm.nih.gov/pubmed/22532842
http://dx.doi.org/10.1371/journal.pone.0035159

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