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Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years

The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles case...

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Autores principales: Zhang, Yan, Xu, Songtao, Wang, Huiling, Zhu, Zhen, Ji, Yixin, Liu, Chunyu, Zhang, Xiaojie, Sun, Liwei, Zhou, Jianhui, Lu, Peishan, Hu, Ying, Feng, Daxing, Zhang, Zhenying, Wang, Changyin, Fang, Xueqiang, Zheng, Huanying, Liu, Leng, Sun, Xiaodong, Tang, Wei, Wang, Yan, Liu, Yan, Gao, Hui, Tian, Hong, Ma, Jiangtao, Gu, Suyi, Wang, Shuang, Feng, Yan, Bo, Fang, Liu, Jianfeng, Si, Yuan, Zhou, Shujie, Ma, Yuyan, Wu, Shengwei, Zhou, Shunde, Li, Fangcai, Ding, Zhengrong, Yang, Zhaohui, Rota, Paul A., Featherstone, David, Jee, Youngmee, Bellini, William J., Xu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332093/
https://www.ncbi.nlm.nih.gov/pubmed/22532829
http://dx.doi.org/10.1371/journal.pone.0034401
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author Zhang, Yan
Xu, Songtao
Wang, Huiling
Zhu, Zhen
Ji, Yixin
Liu, Chunyu
Zhang, Xiaojie
Sun, Liwei
Zhou, Jianhui
Lu, Peishan
Hu, Ying
Feng, Daxing
Zhang, Zhenying
Wang, Changyin
Fang, Xueqiang
Zheng, Huanying
Liu, Leng
Sun, Xiaodong
Tang, Wei
Wang, Yan
Liu, Yan
Gao, Hui
Tian, Hong
Ma, Jiangtao
Gu, Suyi
Wang, Shuang
Feng, Yan
Bo, Fang
Liu, Jianfeng
Si, Yuan
Zhou, Shujie
Ma, Yuyan
Wu, Shengwei
Zhou, Shunde
Li, Fangcai
Ding, Zhengrong
Yang, Zhaohui
Rota, Paul A.
Featherstone, David
Jee, Youngmee
Bellini, William J.
Xu, Wenbo
author_facet Zhang, Yan
Xu, Songtao
Wang, Huiling
Zhu, Zhen
Ji, Yixin
Liu, Chunyu
Zhang, Xiaojie
Sun, Liwei
Zhou, Jianhui
Lu, Peishan
Hu, Ying
Feng, Daxing
Zhang, Zhenying
Wang, Changyin
Fang, Xueqiang
Zheng, Huanying
Liu, Leng
Sun, Xiaodong
Tang, Wei
Wang, Yan
Liu, Yan
Gao, Hui
Tian, Hong
Ma, Jiangtao
Gu, Suyi
Wang, Shuang
Feng, Yan
Bo, Fang
Liu, Jianfeng
Si, Yuan
Zhou, Shujie
Ma, Yuyan
Wu, Shengwei
Zhou, Shunde
Li, Fangcai
Ding, Zhengrong
Yang, Zhaohui
Rota, Paul A.
Featherstone, David
Jee, Youngmee
Bellini, William J.
Xu, Wenbo
author_sort Zhang, Yan
collection PubMed
description The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%–100% and 84.7%–100%, H1b were 97.1%–100% and 95.3%–100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years.
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spelling pubmed-33320932012-04-24 Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years Zhang, Yan Xu, Songtao Wang, Huiling Zhu, Zhen Ji, Yixin Liu, Chunyu Zhang, Xiaojie Sun, Liwei Zhou, Jianhui Lu, Peishan Hu, Ying Feng, Daxing Zhang, Zhenying Wang, Changyin Fang, Xueqiang Zheng, Huanying Liu, Leng Sun, Xiaodong Tang, Wei Wang, Yan Liu, Yan Gao, Hui Tian, Hong Ma, Jiangtao Gu, Suyi Wang, Shuang Feng, Yan Bo, Fang Liu, Jianfeng Si, Yuan Zhou, Shujie Ma, Yuyan Wu, Shengwei Zhou, Shunde Li, Fangcai Ding, Zhengrong Yang, Zhaohui Rota, Paul A. Featherstone, David Jee, Youngmee Bellini, William J. Xu, Wenbo PLoS One Research Article The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%–100% and 84.7%–100%, H1b were 97.1%–100% and 95.3%–100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years. Public Library of Science 2012-04-20 /pmc/articles/PMC3332093/ /pubmed/22532829 http://dx.doi.org/10.1371/journal.pone.0034401 Text en Zhang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Yan
Xu, Songtao
Wang, Huiling
Zhu, Zhen
Ji, Yixin
Liu, Chunyu
Zhang, Xiaojie
Sun, Liwei
Zhou, Jianhui
Lu, Peishan
Hu, Ying
Feng, Daxing
Zhang, Zhenying
Wang, Changyin
Fang, Xueqiang
Zheng, Huanying
Liu, Leng
Sun, Xiaodong
Tang, Wei
Wang, Yan
Liu, Yan
Gao, Hui
Tian, Hong
Ma, Jiangtao
Gu, Suyi
Wang, Shuang
Feng, Yan
Bo, Fang
Liu, Jianfeng
Si, Yuan
Zhou, Shujie
Ma, Yuyan
Wu, Shengwei
Zhou, Shunde
Li, Fangcai
Ding, Zhengrong
Yang, Zhaohui
Rota, Paul A.
Featherstone, David
Jee, Youngmee
Bellini, William J.
Xu, Wenbo
Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
title Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
title_full Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
title_fullStr Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
title_full_unstemmed Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
title_short Single Endemic Genotype of Measles Virus Continuously Circulating in China for at Least 16 Years
title_sort single endemic genotype of measles virus continuously circulating in china for at least 16 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332093/
https://www.ncbi.nlm.nih.gov/pubmed/22532829
http://dx.doi.org/10.1371/journal.pone.0034401
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