Axonal transport deficit in a KIF5A(–/–) mouse model

Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder preferentially affecting the longest corticospinal axons. More than 40 HSP genetic loci have been identified, among them SPG10, an autosomal dominant HSP caused by point mutations in the neuronal kinesin heavy chain protein KIF5A. C...

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Detalles Bibliográficos
Autores principales: Karle, Kathrin N., Möckel, Diana, Reid, Evan, Schöls, Ludger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332386/
https://www.ncbi.nlm.nih.gov/pubmed/22466687
http://dx.doi.org/10.1007/s10048-012-0324-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332386/
https://www.ncbi.nlm.nih.gov/pubmed/22466687
http://dx.doi.org/10.1007/s10048-012-0324-y

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