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Role of denosumab in the management of skeletal complications in patients with bone metastases from solid tumors
Skeletal-related events (SREs) including pain, fractures, and hypercalcemia are a major source of morbidity for cancer patients with bone metastases. The receptor activator of NF-κB ligand (RANKL) is a key mediator of osteoclast formation and activity in normal bone physiology as well as cancer-indu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333824/ https://www.ncbi.nlm.nih.gov/pubmed/22532777 http://dx.doi.org/10.2147/BTT.S20677 |