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Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts

Uncoupling between DNA polymerases and helicase activities at replication forks, induced by diverse DNA lesions or replication inhibitors, generate long stretches of primed single-stranded DNA that is implicated in activation of the S-phase checkpoint. It is currently unclear whether nucleation of t...

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Detalles Bibliográficos
Autores principales: Recolin, Bénédicte, Van Der Laan, Siem, Maiorano, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333866/
https://www.ncbi.nlm.nih.gov/pubmed/22187152
http://dx.doi.org/10.1093/nar/gkr1241