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Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication
DNA topology plays a crucial role in all living cells. In prokaryotes, negative supercoiling is required to initiate replication and either negative or positive supercoiling assists decatenation. The role of DNA knots, however, remains a mystery. Knots are very harmful for cells if not removed effic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333868/ https://www.ncbi.nlm.nih.gov/pubmed/22187153 http://dx.doi.org/10.1093/nar/gkr1237 |