Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

BACKGROUND: The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by upstream kinases (AMPKKs) that hav...

Descripción completa

Detalles Bibliográficos
Autores principales: Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, Alessi, Dario R, Hardie, D Grahame
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC333410/
https://www.ncbi.nlm.nih.gov/pubmed/14511394
http://dx.doi.org/10.1186/1475-4924-2-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC333410/
https://www.ncbi.nlm.nih.gov/pubmed/14511394
http://dx.doi.org/10.1186/1475-4924-2-28

Ejemplares similares