Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

The role of inflammation in the progression of neurodegenerative disease remains unclear. We have shown that systemic bacterial insults accelerate disease progression in animals and in patients with Alzheimer’s disease. Disease exacerbation is associated with exaggerated CNS inflammatory responses t...

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Detalles Bibliográficos
Autores principales: Field, Robert, Campion, Suzanne, Warren, Colleen, Murray, Carol, Cunningham, Colm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334265/
https://www.ncbi.nlm.nih.gov/pubmed/20399848
http://dx.doi.org/10.1016/j.bbi.2010.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334265/
https://www.ncbi.nlm.nih.gov/pubmed/20399848
http://dx.doi.org/10.1016/j.bbi.2010.04.004

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