Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

Ultra-deep targeted sequencing (UDT-Seq) can identify subclonal somatic mutations in tumor samples. Early assays' limited breadth and depth restrict their clinical utility. Here, we target 71 kb of mutational hotspots in 42 cancer genes. We present novel methods enhancing both laboratory workfl...

Descripción completa

Detalles Bibliográficos
Autores principales: Harismendy, Olivier, Schwab, Richard B, Bao, Lei, Olson, Jeff, Rozenzhak, Sophie, Kotsopoulos, Steve K, Pond, Stephanie, Crain, Brian, Chee, Mark S, Messer, Karen, Link, Darren R, Frazer, Kelly A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334619/
https://www.ncbi.nlm.nih.gov/pubmed/22185227
http://dx.doi.org/10.1186/gb-2011-12-12-r124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334619/
https://www.ncbi.nlm.nih.gov/pubmed/22185227
http://dx.doi.org/10.1186/gb-2011-12-12-r124

Ejemplares similares