Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast

Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing endogenous QN-rich proteins in the aggregated (p...

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Detalles Bibliográficos
Autores principales: Gong, He, Romanova, Nina V., Allen, Kim D., Chandramowlishwaran, Pavithra, Gokhale, Kavita, Newnam, Gary P., Mieczkowski, Piotr, Sherman, Michael Y., Chernoff, Yury O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334884/
https://www.ncbi.nlm.nih.gov/pubmed/22536159
http://dx.doi.org/10.1371/journal.pgen.1002634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334884/
https://www.ncbi.nlm.nih.gov/pubmed/22536159
http://dx.doi.org/10.1371/journal.pgen.1002634

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