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Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

Nlrp1b is a NOD-like receptor that detects the catalytic activity of anthrax lethal toxin and subsequently co-oligomerizes into a pro-caspase-1 activation platform known as an inflammasome. Nlrp1b has two domains that promote oligomerization: a NACHT domain, which is a member of the AAA+ ATPase fami...

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Detalles Bibliográficos
Autores principales: Frew, Bradley C., Joag, Vineet R., Mogridge, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334886/
https://www.ncbi.nlm.nih.gov/pubmed/22536155
http://dx.doi.org/10.1371/journal.ppat.1002659