Deficient Signaling via Alk2 (Acvr1) Leads to Bicuspid Aortic Valve Development

Bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly in humans. Despite recent advances, the molecular basis of BAV development is poorly understood. Previously it has been shown that mutations in the Notch1 gene lead to BAV and valve calcification both in human and mice, and mi...

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Detalles Bibliográficos
Autores principales: Thomas, Penny S., Sridurongrit, Somyoth, Ruiz-Lozano, Pilar, Kaartinen, Vesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334911/
https://www.ncbi.nlm.nih.gov/pubmed/22536403
http://dx.doi.org/10.1371/journal.pone.0035539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334911/
https://www.ncbi.nlm.nih.gov/pubmed/22536403
http://dx.doi.org/10.1371/journal.pone.0035539

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