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Deficient Signaling via Alk2 (Acvr1) Leads to Bicuspid Aortic Valve Development
Bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly in humans. Despite recent advances, the molecular basis of BAV development is poorly understood. Previously it has been shown that mutations in the Notch1 gene lead to BAV and valve calcification both in human and mice, and mi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334911/ https://www.ncbi.nlm.nih.gov/pubmed/22536403 http://dx.doi.org/10.1371/journal.pone.0035539 |