Modulation of the Activity of Sp Transcription Factors by Mithramycin Analogues as a New Strategy for Treatment of Metastatic Prostate Cancer

Deregulated activity of transcription factors (TFs) of the Sp/KLF family, like Sp1, Sp3 and Sp4, and consequent over-expression of Sp-regulated genes occur frequently in human cancers. This provides the rationale for development of inhibitors of Sp TFs as cancer therapeutics. Mithramycin A (MTM-A) i...

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Detalles Bibliográficos
Autores principales: Malek, Anastasia, Núñez, Luz-Elena, Magistri, Marco, Brambilla, Lara, Jovic, Sandra, Carbone, Giuseppina M., Morís, Francisco, Catapano, Carlo V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334962/
https://www.ncbi.nlm.nih.gov/pubmed/22545098
http://dx.doi.org/10.1371/journal.pone.0035130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334962/
https://www.ncbi.nlm.nih.gov/pubmed/22545098
http://dx.doi.org/10.1371/journal.pone.0035130

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