The DNA Glycosylases Ogg1 and Nth1 Do Not Contribute to Ig Class Switching in Activated Mouse Splenic B Cells

During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1. Ogg1 and Nth1 excise oxidized bases, and nick the resulting ab...

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Detalles Bibliográficos
Autores principales: Ucher, Anna J., Linehan, Erin K., Teebor, George W., Schrader, Carol E., Stavnezer, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334981/
https://www.ncbi.nlm.nih.gov/pubmed/22536455
http://dx.doi.org/10.1371/journal.pone.0036061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334981/
https://www.ncbi.nlm.nih.gov/pubmed/22536455
http://dx.doi.org/10.1371/journal.pone.0036061

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