Asymmetric Bidirectional Transcription from the FSHD-Causing D4Z4 Array Modulates DUX4 Production

Facioscapulohumeral Disease (FSHD) is a dominantly inherited progressive myopathy associated with aberrant production of the transcription factor, Double Homeobox Protein 4 (DUX4). The expression of DUX4 depends on an open chromatin conformation of the D4Z4 macrosatellite array and a specific haplot...

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Detalles Bibliográficos
Autores principales: Block, Gregory J., Petek, Lisa M., Narayanan, Divya, Amell, Amanda M., Moore, James M., Rabaia, Natalia A., Tyler, Ashlee, van der Maarel, Silvere M., Tawil, Rabi, Filippova, Galina N., Miller, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334996/
https://www.ncbi.nlm.nih.gov/pubmed/22536400
http://dx.doi.org/10.1371/journal.pone.0035532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334996/
https://www.ncbi.nlm.nih.gov/pubmed/22536400
http://dx.doi.org/10.1371/journal.pone.0035532

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