Pleiotropy of Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Self-Renewal of Embryonic Stem Cells from Refractory Mouse Strains

BACKGROUND: Inhibition of glycogen synthase kinase-3 (GSK-3) improves the efficiency of embryonic stem (ES) cell derivation from various strains of mice and rats, as well as dramatically promotes ES cell self-renewal potential. β-catenin has been reported to be involved in the maintenance of self-re...

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Detalles Bibliográficos
Autores principales: Ye, Shoudong, Tan, Li, Yang, Rongqing, Fang, Bo, Qu, Su, Schulze, Eric N., Song, Houyan, Ying, Qilong, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335080/
https://www.ncbi.nlm.nih.gov/pubmed/22540008
http://dx.doi.org/10.1371/journal.pone.0035892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335080/
https://www.ncbi.nlm.nih.gov/pubmed/22540008
http://dx.doi.org/10.1371/journal.pone.0035892

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