Cargando…
MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells
BACKGROUND: Regulator of G-protein Signaling 4 (RGS4) plays an important role in regulating smooth muscle contraction, cardiac development, neural plasticity and psychiatric disorder. However, the underlying regulatory mechanisms remain elusive. Our recent studies have shown that upregulation of Rgs...
Autores principales: | Zhang, Yonggang, Li, Fang, Liu, Shu, Wang, Hong, Mahavadi, Sunila, Murthy, Karnam S., Khalili, Kamel, Hu, Wenhui |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335800/ https://www.ncbi.nlm.nih.gov/pubmed/22545125 http://dx.doi.org/10.1371/journal.pone.0035646 |
Ejemplares similares
-
D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells
por: Ryabinina, Olga P, et al.
Publicado: (2006) -
Diabetes-induced oxidative stress mediates upregulation of RhoA/Rho kinase pathway and hypercontractility of gastric smooth muscle
por: Mahavadi, Sunila, et al.
Publicado: (2017) -
Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA
por: Sriwai, Wimolpak, et al.
Publicado: (2013) -
Analysis of MAP kinase MPK4/MEKK1/MKK genes of Carica papaya L. comparative to other plant homologues
por: Hamid, Muhammad Hanam, et al.
Publicado: (2017) -
A Non-Redundant Role for Drosophila Mkk4 and Hemipterous/Mkk7 in TAK1-Mediated Activation of JNK
por: Geuking, Peter, et al.
Publicado: (2009)