Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the maintenance and tumorigenicity of mouse lung cancer stem-like cells (CSC). Mmp10 is highly expressed in oncosphere cultur...

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Detalles Bibliográficos
Autores principales: Justilien, Verline, Regala, Roderick P., Tseng, I-Chu, Walsh, Michael P., Batra, Jyotica, Radisky, Evette S., Murray, Nicole R., Fields, Alan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335833/
https://www.ncbi.nlm.nih.gov/pubmed/22545096
http://dx.doi.org/10.1371/journal.pone.0035040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335833/
https://www.ncbi.nlm.nih.gov/pubmed/22545096
http://dx.doi.org/10.1371/journal.pone.0035040

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