Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a diverse subset of the Pfizer corporate collection agai...

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Detalles Bibliográficos
Autores principales: Bell, Andrew S., Mills, James E., Williams, Gareth P., Brannigan, James A., Wilkinson, Anthony J., Parkinson, Tanya, Leatherbarrow, Robin J., Tate, Edward W., Holder, Anthony A., Smith, Deborah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335879/
https://www.ncbi.nlm.nih.gov/pubmed/22545171
http://dx.doi.org/10.1371/journal.pntd.0001625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335879/
https://www.ncbi.nlm.nih.gov/pubmed/22545171
http://dx.doi.org/10.1371/journal.pntd.0001625

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