Cellular mechanism of bile acid-accelerated hepatocyte polarity

We recently discovered that the major mammalian bile acid, taurocholate, accelerated polarity in primary rat hepatocytes. Taurocholate increased cellular cAMP and signals through an Epac-Rap1-MEK-LKB1-AMPK pathway for its polarity effect. This review discusses possible mechanisms for how taurocholat...

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Detalles Bibliográficos
Autores principales: Fu, Dong, Lippincott-Schwartz, Jennifer, Arias, Irwin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2011
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337160/
https://www.ncbi.nlm.nih.gov/pubmed/22545229
http://dx.doi.org/10.4161/sgtp.18087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337160/
https://www.ncbi.nlm.nih.gov/pubmed/22545229
http://dx.doi.org/10.4161/sgtp.18087

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