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Cellular mechanism of bile acid-accelerated hepatocyte polarity

We recently discovered that the major mammalian bile acid, taurocholate, accelerated polarity in primary rat hepatocytes. Taurocholate increased cellular cAMP and signals through an Epac-Rap1-MEK-LKB1-AMPK pathway for its polarity effect. This review discusses possible mechanisms for how taurocholat...

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Detalles Bibliográficos
Autores principales:	Fu, Dong, Lippincott-Schwartz, Jennifer, Arias, Irwin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2011
Materias:	Extra View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337160/ https://www.ncbi.nlm.nih.gov/pubmed/22545229 http://dx.doi.org/10.4161/sgtp.18087

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