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Glia instruct developmental neuronal remodeling through TGF-βsignaling

Neural circuits are remodeled in response to developmental and environmental cues. Here we show that glia secrets Myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial Myoglianin up-regulates neuronal expression of an ecdysone nuclear receptor that triggers neu...

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Detalles Bibliográficos
Autores principales: Awasaki, Takeshi, Huang, Ya-ling, O’Connor, Michael B, Lee, Tzumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337551/
https://www.ncbi.nlm.nih.gov/pubmed/21685919
http://dx.doi.org/10.1038/nn.2833