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Role of Leukotrienes on Protozoan and Helminth Infections
Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bact...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337730/ https://www.ncbi.nlm.nih.gov/pubmed/22577251 http://dx.doi.org/10.1155/2012/595694 |
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author | Rogerio, Alexandre P. Anibal, Fernanda F. |
author_facet | Rogerio, Alexandre P. Anibal, Fernanda F. |
author_sort | Rogerio, Alexandre P. |
collection | PubMed |
description | Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis. In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections. Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections. |
format | Online Article Text |
id | pubmed-3337730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33377302012-05-10 Role of Leukotrienes on Protozoan and Helminth Infections Rogerio, Alexandre P. Anibal, Fernanda F. Mediators Inflamm Review Article Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. Interestingly, some proteins from the saliva of insect vectors that transmit protozoans and secreted protein from helminth could bind LTs and may consequently modulate the course of infection or pathogenesis. In addition, the decreased production of LTs in immunocompromised individuals might modulate the pathophysiology of helminth and protozoan infections. Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections. Hindawi Publishing Corporation 2012 2012-04-10 /pmc/articles/PMC3337730/ /pubmed/22577251 http://dx.doi.org/10.1155/2012/595694 Text en Copyright © 2012 A. P. Rogerio and F. F. Anibal. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rogerio, Alexandre P. Anibal, Fernanda F. Role of Leukotrienes on Protozoan and Helminth Infections |
title | Role of Leukotrienes on Protozoan and Helminth Infections |
title_full | Role of Leukotrienes on Protozoan and Helminth Infections |
title_fullStr | Role of Leukotrienes on Protozoan and Helminth Infections |
title_full_unstemmed | Role of Leukotrienes on Protozoan and Helminth Infections |
title_short | Role of Leukotrienes on Protozoan and Helminth Infections |
title_sort | role of leukotrienes on protozoan and helminth infections |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337730/ https://www.ncbi.nlm.nih.gov/pubmed/22577251 http://dx.doi.org/10.1155/2012/595694 |
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