Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells

Mdm2 is the major negative regulator of p53 tumor suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2...

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Detalles Bibliográficos
Autores principales: Wade, Mark, Li, Yao-Cheng, Matani, Anand, Braun, Simon M G, Milanesi, Francesca, Rodewald, Luo Wei, Wahl, Geoffrey M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337965/
https://www.ncbi.nlm.nih.gov/pubmed/22266850
http://dx.doi.org/10.1038/onc.2011.625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337965/
https://www.ncbi.nlm.nih.gov/pubmed/22266850
http://dx.doi.org/10.1038/onc.2011.625

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