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Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells
Mdm2 is the major negative regulator of p53 tumor suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337965/ https://www.ncbi.nlm.nih.gov/pubmed/22266850 http://dx.doi.org/10.1038/onc.2011.625 |