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Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells
Phage display screening allows the study of functional protein–protein interactions at the cell surface, but investigating intracellular organelles remains a challenge. Here we introduce internalizing-phage libraries to identify clones that enter mammalian cells through a receptor-independent mechan...
Autores principales: | Rangel, Roberto, Guzman-Rojas, Liliana, le Roux, Lucia G., Staquicini, Fernanda I., Hosoya, Hitomi, Barbu, E. Magda, Ozawa, Michael G., Nie, Jing, Jr, Kenneth Dunner, Langley, Robert R., Sage, E. Helene, Koivunen, Erkki, Gelovani, Juri G., Lobb, Roy R., Sidman, Richard L., Pasqualini, Renata, Arap, Wadih |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337985/ https://www.ncbi.nlm.nih.gov/pubmed/22510693 http://dx.doi.org/10.1038/ncomms1773 |
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