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PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia

Phosphorylation of the activation domain of protein kinase C (PKC) isoforms is essential to start a conformational change that results in an active catalytic domain. This activation is necessary not only for newly synthesized molecules, but also for kinase molecules that become dephosphorylated and...

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Detalles Bibliográficos
Autores principales: Mashukova, Anastasia, Forteza, Radia, Wald, Flavia A., Salas, Pedro J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338434/
https://www.ncbi.nlm.nih.gov/pubmed/22398726
http://dx.doi.org/10.1091/mbc.E11-12-0988