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A VE-cadherin–PAR3–α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells

Phospholipase A(2) enzymes hydrolyze phospholipids to liberate arachidonic acid for the biosynthesis of prostaglandins and leukotrienes. In the vascular endothelium, group IV phospholipase A(2)α (cPLA(2)α) enzyme activity is regulated by reversible association with the Golgi apparatus. Here we provi...

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Detalles Bibliográficos
Autores principales: Odell, Adam F., Hollstein, Monica, Ponnambalam, Sreenivasan, Walker, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338442/
https://www.ncbi.nlm.nih.gov/pubmed/22398721
http://dx.doi.org/10.1091/mbc.E11-08-0694