Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers

BACKGROUND: Modified nucleotides are increasingly being utilized in the de novo selection of aptamers for enhancing their drug-like character and abolishing the need for time consuming trial-and-error based post-selection modifications. Locked nucleic acid (LNA) is one of the most prominent and succ...

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Detalles Bibliográficos
Autores principales: Crouzier, Lucile, Dubois, Camille, Edwards, Stacey L., Lauridsen, Lasse H., Wengel, Jesper, Veedu, Rakesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338489/
https://www.ncbi.nlm.nih.gov/pubmed/22558297
http://dx.doi.org/10.1371/journal.pone.0035990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338489/
https://www.ncbi.nlm.nih.gov/pubmed/22558297
http://dx.doi.org/10.1371/journal.pone.0035990

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