Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

BACKGROUND: Type 2 diabetes is characterized by pancreatic β-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that the signalling cascade activated by lipopolysaccharides (LPS) binding to Toll-Like Receptor 4 (TLR4) exerts deleterious effects on pancreatic...

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Detalles Bibliográficos
Autores principales: Amyot, Julie, Semache, Meriem, Ferdaoussi, Mourad, Fontés, Ghislaine, Poitout, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338606/
https://www.ncbi.nlm.nih.gov/pubmed/22558381
http://dx.doi.org/10.1371/journal.pone.0036200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338606/
https://www.ncbi.nlm.nih.gov/pubmed/22558381
http://dx.doi.org/10.1371/journal.pone.0036200

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