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Why Do Protein Folding Rates Correlate with Metrics of Native Topology?

For almost 15 years, the experimental correlation between protein folding rates and the contact order parameter has been under scrutiny. Here, we use a simple simulation model combined with a native-centric interaction potential to investigate the physical roots of this empirical observation. We sim...

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Detalles Bibliográficos
Autores principales: Faísca, Patrícia F. N., Travasso, Rui D. M., Parisi, Andrea, Rey, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338708/
https://www.ncbi.nlm.nih.gov/pubmed/22558173
http://dx.doi.org/10.1371/journal.pone.0035599