A Small Molecule SMAC Mimic LBW242 Potentiates TRAIL- and Anticancer Drug-Mediated Cell Death of Ovarian Cancer Cells

BACKGROUND: Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on...

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Detalles Bibliográficos
Autores principales: Petrucci, Eleonora, Pasquini, Luca, Bernabei, Manuela, Saulle, Ernestina, Biffoni, Mauro, Accarpio, Fabio, Sibio, Simone, Di Giorgio, Angelo, Di Donato, Violante, Casorelli, Assunta, Benedetti-Panici, Pierluigi, Testa, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338831/
https://www.ncbi.nlm.nih.gov/pubmed/22558117
http://dx.doi.org/10.1371/journal.pone.0035073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338831/
https://www.ncbi.nlm.nih.gov/pubmed/22558117
http://dx.doi.org/10.1371/journal.pone.0035073

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