JKA97, a Novel Benzylidene Analog of Harmine, Exerts Anti-Cancer Effects by Inducing G1 Arrest, Apoptosis, and p53-Independent Up-Regulation of p21

JKA97, a benzylidene analog of harmine, has been found to be a promising drug candidate for human cancer therapy, although the underlying molecular mechanisms have not been fully demonstrated. In this study, we evaluated the effects of JKA97 on human breast cancer cells in vitro and in vivo. JKA97 i...

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Detalles Bibliográficos
Autores principales: Yang, Xinyi, Wang, Wei, Qin, Jiang-Jiang, Wang, Ming-Hai, Sharma, Horrick, Buolamwini, John K., Wang, Hui, Zhang, Ruiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338851/
https://www.ncbi.nlm.nih.gov/pubmed/22558087
http://dx.doi.org/10.1371/journal.pone.0034303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338851/
https://www.ncbi.nlm.nih.gov/pubmed/22558087
http://dx.doi.org/10.1371/journal.pone.0034303

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