Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication

BACKGROUND: Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends o...

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Detalles Bibliográficos
Autores principales: Chhatwal, Patrick, Bankwitz, Dorothea, Gentzsch, Juliane, Frentzen, Anne, Schult, Philipp, Lohmann, Volker, Pietschmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338857/
https://www.ncbi.nlm.nih.gov/pubmed/22558311
http://dx.doi.org/10.1371/journal.pone.0036029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338857/
https://www.ncbi.nlm.nih.gov/pubmed/22558311
http://dx.doi.org/10.1371/journal.pone.0036029

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