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Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication

BACKGROUND: Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends o...

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Detalles Bibliográficos
Autores principales:	Chhatwal, Patrick, Bankwitz, Dorothea, Gentzsch, Juliane, Frentzen, Anne, Schult, Philipp, Lohmann, Volker, Pietschmann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338857/ https://www.ncbi.nlm.nih.gov/pubmed/22558311 http://dx.doi.org/10.1371/journal.pone.0036029

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