Exploiting a natural conformational switch to engineer an Interleukin-2 superkine

The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of leukocytes, including T cells and natural killer (NK) cells(1–3). Considerable effort has been invested using IL-2 as a therapeutic agent for a variety of immune disorders ranging from AIDS to cancer. However,...

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Detalles Bibliográficos
Autores principales: Levin, Aron M., Bates, Darren L., Ring, Aaron M., Krieg, Carsten, Lin, Jack T., Su, Leon, Moraga, Ignacio L., Raeber, Miro E., Bowman, Gregory R., Novick, Paul, Pande, Vijay S., Fathman, C. Garrison, Boyman, Onur, Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338870/
https://www.ncbi.nlm.nih.gov/pubmed/22446627
http://dx.doi.org/10.1038/nature10975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338870/
https://www.ncbi.nlm.nih.gov/pubmed/22446627
http://dx.doi.org/10.1038/nature10975

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