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Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation

Endothelial cells normally line the vasculature and remain quiescent. However, these cells can be rapidly stimulated to undergo morphogenesis and initiate new blood vessel formation given the proper cues. This study reports a new mechanism for initiating angiogenic sprout formation that involves vim...

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Detalles Bibliográficos
Autores principales: Kwak, Hyeong-Il, Kang, Hojin, Dave, Jui M., Mendoza, E. Adriana, Su, Shih-Chi, Maxwell, Steve A., Bayless, Kayla J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338915/
https://www.ncbi.nlm.nih.gov/pubmed/22407449
http://dx.doi.org/10.1007/s10456-012-9262-4