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Standard Error of Empirical Bayes Estimate in NONMEM® VI

The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error o...

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Detalles Bibliográficos
Autores principales: Kang, Dongwoo, Bae, Kyun-Seop, Houk, Brett E., Savic, Radojka M., Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339294/
https://www.ncbi.nlm.nih.gov/pubmed/22563254
http://dx.doi.org/10.4196/kjpp.2012.16.2.97