Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α(2)δ-1 Subunit

How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is partially retained in the neuronal endoplasmic reticulum (ER). As these mice age, they develop ataxia and massive degeneration of cerebellar...

Descripción completa

Detalles Bibliográficos
Autores principales: Senatore, Assunta, Colleoni, Simona, Verderio, Claudia, Restelli, Elena, Morini, Raffaella, Condliffe, Steven B., Bertani, Ilaria, Mantovani, Susanna, Canovi, Mara, Micotti, Edoardo, Forloni, Gianluigi, Dolphin, Annette C., Matteoli, Michela, Gobbi, Marco, Chiesa, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339322/
https://www.ncbi.nlm.nih.gov/pubmed/22542184
http://dx.doi.org/10.1016/j.neuron.2012.02.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339322/
https://www.ncbi.nlm.nih.gov/pubmed/22542184
http://dx.doi.org/10.1016/j.neuron.2012.02.027

Ejemplares similares