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Autocrine PDGF stimulation in malignancies

Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribu...

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Detalles Bibliográficos
Autor principal: Heldin, Carl-Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339540/
https://www.ncbi.nlm.nih.gov/pubmed/22512244
http://dx.doi.org/10.3109/03009734.2012.658119
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author Heldin, Carl-Henrik
author_facet Heldin, Carl-Henrik
author_sort Heldin, Carl-Henrik
collection PubMed
description Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors.
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spelling pubmed-33395402012-05-24 Autocrine PDGF stimulation in malignancies Heldin, Carl-Henrik Ups J Med Sci Review Article Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors. Informa Healthcare 2012-05 2012-04-19 /pmc/articles/PMC3339540/ /pubmed/22512244 http://dx.doi.org/10.3109/03009734.2012.658119 Text en © Informa Healthcare http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Review Article
Heldin, Carl-Henrik
Autocrine PDGF stimulation in malignancies
title Autocrine PDGF stimulation in malignancies
title_full Autocrine PDGF stimulation in malignancies
title_fullStr Autocrine PDGF stimulation in malignancies
title_full_unstemmed Autocrine PDGF stimulation in malignancies
title_short Autocrine PDGF stimulation in malignancies
title_sort autocrine pdgf stimulation in malignancies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339540/
https://www.ncbi.nlm.nih.gov/pubmed/22512244
http://dx.doi.org/10.3109/03009734.2012.658119
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