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Hypercapnia Induces Cleavage and Nuclear Localization of RelB Protein, Giving Insight into CO(2) Sensing and Signaling

Carbon dioxide (CO(2)) is increasingly being appreciated as an intracellular signaling molecule that affects inflammatory and immune responses. Elevated arterial CO(2) (hypercapnia) is encountered in a range of clinical conditions, including chronic obstructive pulmonary disease, and as a consequenc...

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Detalles Bibliográficos
Autores principales: Oliver, Kathryn M., Lenihan, Colin R., Bruning, Ulrike, Cheong, Alex, Laffey, John G., McLoughlin, Paul, Taylor, Cormac T., Cummins, Eoin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340129/
https://www.ncbi.nlm.nih.gov/pubmed/22396550
http://dx.doi.org/10.1074/jbc.M112.347971