Cross-seeding and Conformational Selection between Three- and Four-repeat Human Tau Proteins

In Alzheimer's disease and frontotemporal dementias, the microtubule-associated protein Tau forms intracellular paired helical filaments. The filaments can form not only by the full-length human Tau protein, but also by the three repeated (K19) or four repeated (K18) Tau segments. However, of i...

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Detalles Bibliográficos
Autores principales: Yu, Xiang, Luo, Yin, Dinkel, Paul, Zheng, Jie, Wei, Guanghong, Margittai, Martin, Nussinov, Ruth, Ma, Buyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340261/
https://www.ncbi.nlm.nih.gov/pubmed/22393063
http://dx.doi.org/10.1074/jbc.M112.340794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340261/
https://www.ncbi.nlm.nih.gov/pubmed/22393063
http://dx.doi.org/10.1074/jbc.M112.340794

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