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Cross-seeding and Conformational Selection between Three- and Four-repeat Human Tau Proteins

In Alzheimer's disease and frontotemporal dementias, the microtubule-associated protein Tau forms intracellular paired helical filaments. The filaments can form not only by the full-length human Tau protein, but also by the three repeated (K19) or four repeated (K18) Tau segments. However, of i...

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Detalles Bibliográficos
Autores principales:	Yu, Xiang, Luo, Yin, Dinkel, Paul, Zheng, Jie, Wei, Guanghong, Margittai, Martin, Nussinov, Ruth, Ma, Buyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340261/ https://www.ncbi.nlm.nih.gov/pubmed/22393063 http://dx.doi.org/10.1074/jbc.M112.340794

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